WG2: Consolidated and Emerging Gene Editing Technologies

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WG2

Description

WG2 will define the set of protocols, reagents, and procedures to be put in common for the network regarding gene editing and CRISPR/CAS technologies. Its members will prepare the protocols, procedures and reagents data base to be uploaded to the network web page for future research. WG2 will evaluate how to implement in the network emerging gene editing technologies such as base editing and prime editing. Furthermore, WG2 will constantly identify new technologies arising in the field to be evaluated the network.

Leaders

Pia Johansson

Medical Faculty - Lund Stem Cell Centre

Sebastian Diecke

Max Delbrück Center for Molecular Medicine

Tasks

Compile a list of procedures to include protocols, reagents, instruments, tests and from these attributes, create a comprehensive, well documented, easily searchable database for all procedures identified.
Continuous identification of new emerging technologies
Establishing focus groups for and to test base editing/prime editing/HITI
Establishment of control cell lines harbouring inducible versions of different CAS proteins

Activities

Continuous communication through the network forum and e-mailing list
Teleconference meeting in Q2, Q4, Q6, Q8, Q10, Q12, Q14 & Q16 to summarise and implement tasks among the working group.
Participation and presentation of results in annual symposium in Q4, Q8, Q12 and Q16
Participation in annual training in Q2, Q6, Q10 and Q14
Organise virtual lectures from experts in the field

Major Deliverables

WG2 annual report with activities and Action progress in Q4
WG2 meeting minutes in Q2, Q4, Q6, Q8, Q10, Q12, Q14 &Q16
Annual WG2 comprehensive member data base including protocols, instruments, tests and expertise available from each site. Continuous update procedures database compilation ready for webpage update in Q2, Q4, Q6, Q8, Q10, Q12, Q14 and Q16
Report in new technologies emerging, leading research labs, and industries to interact with and how in Q4, Q8, Q12 and Q16.

Structure

Meet the other Working Groups

WG1: Challenging the Frontiers of Stem Cell and Organoids Technologies

WG1 will define the set of protocols to be evaluated and to be put in common from the reprogramming, iPSC maintenance and culture, 2D differentiation and 3D organoids.

WG3: Quality Control Standardization and Harmonization

WG3 will evaluate, and benchmark the protocols, reagents and procedures used across facilities. WG3 will be the framework that enables this comparison, identifying and establishing standardized best practice with respect to general and quality control procedures, thereby facilitating harmonization through dissemination and adoption.

WG4: Training and Professional Development

WG4 will plan, design, develop and organise the training events, workshops on human development activities required for the network.

WG5: Network Building and Strengthening

The objective of WG5 will be to build, grow and strengthen the ties between members of the CorEuStem Action as well as attracting new members.

WG6: Transversal Management, Exploitation and Dissemination

WG6 will manage and work transversally to integrate and evolve the different technologies and actions in the network, the interactions.

COST

COST (European Cooperation in Science and Technology) is a funding organisation for research and innovation networks. Our Actions help connect research initiatives across Europe and beyond and enable researchers and innovators to grow their ideas in any science and technology field by sharing them with their peers. COST Actions are bottom-up networks with a duration of four years that boost research, innovation and careers.

COST Action CA20140

The COST Action CorEuStem will be comprised of European core facilities that are experts in stem cell biology, differentiation, organoids and gene editing technologies with the aim of developing an efficient and effective consortium for harmonizing procedures and protocols across Europe and beyond.

Action Details

MoU • Memorandum of Understanding
CSO Approval date: 25 May 2021
Action start date: 21 October 2021
Action end date: 20 October 2025

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