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WG2: Consolidated and Emerging Gene Editing Technologies

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WG2: Consolidated and Emerging Gene Editing Technologies

WG2

Description

WG2 defined the set of protocols, reagents, and procedures to be put in common for the network regarding gene editing and CRISPR/CAS technologies. Its members prepared protocols, procedures, and reagents database uploaded on the network web page for future research. WG2 evaluated how to implement in the network emerging gene editing technologies such as base editing and prime editing. Furthermore, WG2 identified new technologies arising in the field to be evaluated the network.

CorEuStem-web-27

Leaders

Pia Johansson
Medical Faculty - Lund Stem Cell Centre
Sebastian Diecke
Max Delbrück Center for ​ Molecular Medicine

Tasks

  • Compile a list of procedures to include protocols, reagents, instruments, tests and from these attributes, create a comprehensive, well documented, easily searchable database for all procedures identified.
  • Continuous identification of new emerging technologies
  • Establishing focus groups for and to test base editing/prime editing/HITI
  • Establishment of control cell lines harbouring inducible versions of different CAS proteins

Activities

  • Continuous communication through the network forum and e-mailing list
  • Teleconference meeting in Q2, Q4, Q6, Q8, Q10, Q12, Q14 & Q16 to summarise and implement tasks among the working group.
  • Participation and presentation of results in annual symposium in Q4, Q8, Q12 and Q16
  • Participation in annual training in Q2, Q6, Q10 and Q14
  • Organise virtual lectures from experts in the field

Major Deliverables

  • WG2 annual report with activities and Action progress in Q4
  • WG2 meeting minutes in Q2, Q4, Q6, Q8, Q10, Q12, Q14 &Q16
  • Annual WG2 comprehensive member data base including protocols, instruments, tests and expertise available from each site. Continuous update procedures database compilation ready for webpage update in Q2, Q4, Q6, Q8, Q10, Q12, Q14 and Q16
  • Report in new technologies emerging, leading research labs, and industries to interact with and how in Q4, Q8, Q12 and Q16.

Structure

Meet the other Working Groups

WG1: Challenging the Frontiers of Stem Cell and Organoids Technologies

WG1 aimed to define the set of protocols associated with reprogramming, PSC maintenance, 2D differentiation, and organoids to be shared with the network.

WG3: Quality Control Standardization and Harmonization

WG3 evaluated and benchmarked protocols, reagents and procedures used across facilities. WG3 represented the framework enabling this comparison, identifying and establishing standardised best practice with respect to general public and quality control procedures, thereby facilitating harmonisation through dissemination and adoption.

WG4: Training and Professional Development

WG4 designed, organised, and developed training events, workshops, and webinars on subjects related to WG1, WG2, and WG3.

WG5: Network Building and Strengthening

The objective of WG5 is to build, grow, and strengthen the ties between members of the CorEuStem Action as well as attracting new members. WG5 organised annual meetings and smaller workshops to disseminate information, discuss the latest findings, and showcase and share newly developed technologies.

WG6: Transversal Management, Exploitation and Dissemination

WG6 managed and worked transversally to integrate and evolve the different technologies and actions in the network, the interactions. WG6 worked on the transversal exploitation and dissemination plan for the network, identified and promoted sustainability plans for the network and targeted stakeholders and industry partners.